Gamma-aminobutyric acid (GABA)Nws yog ib qho tseem ceeb heev neurotransmitter nyob rau hauv tib neeg lub cev, ua si lub luag hauj lwm tseem ceeb nyob rau hauv lub hauv paus nervous system (CNS). Raws li lub hauv paus inhibitory neurotransmitter, GABA yog lub luag haujlwm rau kev tswj cov neuronal excitability, txhawb kev so, thiab tswj kev sib npaug ntawm lub hlwb. Nws qhov tseem ceeb hauv tib neeg lub cev tsis tuaj yeem hais dhau los, raws li GABA-mediated signaling cuam tshuam ntau yam ntawm cov haujlwm tseem ceeb, los ntawm kev pw tsaug zog thiab kev tswj hwm mus rau cov leeg nqaij.
Kev tswj lub hlwb ua haujlwm
Inhibition ntawm Neurotransmission:
GABA ua raws li ib qho inhibitory neurotransmitter, khi rau cov receptors tshwj xeeb ntawm cov neurons thiab ua rau muaj ntau yam xwm txheej uas ua rau txo qis ntawm neuronal excitability. Cov txheej txheem no yog qhov tseem ceeb hauv kev tiv thaiv overstimulation thiab tswj kom ruaj khov, zoo-tsim neural ib puag ncig. Los ntawm dampening lub firing ntawm neurons, GABA pab rau modulate tag nrho cov theem ntawm neuronal kev ua ub no, xyuas kom meej tias lub hlwb ua hauj lwm nyob rau hauv nws cov kev pom ntau yam (Brickley thiab Mody, 2012).
Kev ntxhov siab thiab txo kev ntxhov siab:
GABAergic system, uas suav nrog kev tsim khoom, tso tawm, thiab teeb liab ntawm GABA, ua lub luag haujlwm tseem ceeb hauv kev tswj hwm kev ntxhov siab thiab kev ntxhov siab hauv lub hlwb. GABA's inhibitory cuam tshuam ntawm kev ua haujlwm neuronal pab tiv thaiv cov cim excitatory cuam tshuam nrog kev ntxhov siab thiab kev ntxhov siab, txhawb lub xeev ntawm kev so thiab kev thaj yeeb (Möhler, 2012). Qhov no mechanism yog tshwj xeeb tshaj yog tseem ceeb nyob rau hauv kev tswj lub physiological thiab puas siab puas ntsws manifestations ntawm kev nyuaj siab, xws li- aminobutyric acid-mediated signaling tuaj yeem txo qhov cuam tshuam ntawm kev cuam tshuam ntev rau kev ntxhov siab.
Kev cai pw tsaug zog
Kev txhawb zog pw tsaug zog:
GABA yog ib qho tseem ceeb hauv kev tswj hwm ntawm kev pw tsaug zog-wake cycles. Los ntawm kev ua haujlwm ntawm lub hlwb tshwj xeeb koom nrog hauv kev tswj hwm kev pw tsaug zog thiab tsaug zog, GABA pab txhawb kev pib thiab tswj kev pw tsaug zog (Winsky-Sommerer, 2009). GABA's inhibitory kev ua haujlwm pab txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawb nqa neurons, tso cai rau lub hlwb hloov mus rau hauv lub xeev ntawm kev so thiab pab txhawb kev hloov mus rau qhov tob, ntau dua cov theem ntawm kev pw tsaug zog.
Kev Tswj Kev Pw Tsaug Zog:
Muab GABA lub luag haujlwm tseem ceeb hauv kev tswj kev pw tsaug zog, cov kws tshawb fawb tau tshawb nrhiav cov kev siv tshuaj kho mob ntawm GABA kev hloov pauv hauv kev kho mob pw tsaug zog. Cov kev tshawb fawb tau pom tias cov tshuaj GABAergic, xws li benzodiazepines thiab non-benzodiazepine hypnotics, tuaj yeem txhim kho kev pw tsaug zog, lub sijhawm, thiab zoo, ua rau lawv muaj txiaj ntsig zoo hauv kev tswj cov mob xws li insomnia (Winsky-Sommerer, 2009). Los ntawm lub hom phiajGamma-aminobutyric acidergic system, cov kev cuam tshuam no tsom mus rau qhov sib npaug ntawm cov kev ua haujlwm neuronal, ua rau txhim kho kev pw tsaug zog thiab zoo dua tag nrho kev pw tsaug zog.
Mood Regulation
Influence rau Mood:
GABA qhov cuam tshuam rau lub hlwb txuas ntxiv tshaj li kev cai pw tsaug zog, vim nws kuj tseem ua lub luag haujlwm tseem ceeb hauv kev hloov mus rau lub siab thiab lub siab lub ntsws. GABAergic system yog sib txuas nrog kev tswj hwm ntawm kev xav, thiab qhov tsis txaus ntseeg hauv GABA qib lossis kev taw qhia tau cuam tshuam nrog ntau yam kev xav tsis zoo, nrog rau kev nyuaj siab thiab kev puas siab puas ntsws bipolar (Brambilla li al., 2003). Los ntawm kev cuam tshuam cov kev ua ntawm lub hlwb hauv cheeb tsam koom nrog hauv kev xav, GABA pab tswj kom muaj kev xav ruaj khov thiab sib npaug.
Muaj peev xwm Therapeutic Applications:
Paub txog qhov kev sib txuas ntawm GABAergic dysfunction thiab mus ob peb vas, cov kws tshawb fawb tau tshawb nrhiav lub peev xwm ntawm GABA-targeting interventions raws li kev xaiv kho mob. Cov tshuaj uas txhim kho GABA signaling, xws li benzodiazepines thiab qee cov tshuaj tiv thaiv kev nyuaj siab, tau pom cov txiaj ntsig tau zoo hauv kev tswj hwm kev xav tsis zoo (Brambilla li al., 2003). Los ntawm kev hais txog qhov tshwm sim ntawm GABAergic imbalances, cov kev kho mob no txhawm rau txo cov tsos mob ntawm kev xav tsis zoo thiab txhim kho kev noj qab haus huv tag nrho ntawm cov tib neeg cuam tshuam los ntawm cov xwm txheej no.
Cov leeg nqaij
Txoj cai ntawm Muscle Tone:
- aminobutyric acid'kev cuam tshuam txuas mus dhau lub ntiaj teb ntawm lub hlwb, vim nws kuj ua lub luag haujlwm tseem ceeb hauv kev tswj cov leeg nqaij thiab kev so lub cev. GABAergic signaling nyob rau hauv tus txha caj qaum thiab lub cev muaj zog cortex pab txhawb rau inhibition ntawm lub cev muaj zog neuron kev ua si, ua rau kom txo tau cov leeg nro thiab txhawb lub xeev ntawm so (Knabl li al., 2008). Cov txheej txheem no yog qhov tseem ceeb rau kev tswj cov leeg nqaij kom zoo thiab tiv thaiv cov leeg nqaij ntau dhau los yog spasms.
Clinical Implications:
Kev sib raug zoo ntawm GABA thiab cov leeg ua haujlwm muaj qhov cuam tshuam tseem ceeb hauv kev kho mob. Cov tshuaj GABAergic, xws li benzodiazepines thiab cov leeg nqaij so, tau ua haujlwm hauv kev tswj hwm ntawm ntau yam kab mob neuromuscular, nrog rau cov leeg nqaij, dystonia, thiab qee hom kev tuag tes tuag taw (Knabl li al., 2008). Los ntawm kev tsom mus rau GABAergic txoj hauv kev, cov kev cuam tshuam no txhawm rau txo cov tsos mob ntawm cov leeg nqaij thiab txhim kho tag nrho lub neej zoo rau cov tib neeg cuam tshuam los ntawm cov xwm txheej zoo li no.
Xaus
Gamma-aminobutyric acid (GABA)yog ib tug ntau yam thiab indispensable neurotransmitter nyob rau hauv tib neeg lub cev, ua si ib tug tseem ceeb luag hauj lwm nyob rau hauv regulating ntau yam physiological functions. Los ntawm nws cov inhibitory ua nyob rau hauv lub hlwb, uas pab tswj kom muaj nuj nqis neuronal thiab txo kev ntxhov siab vim, rau nws txoj kev koom tes nyob rau hauv kev pw tsaug zog tswj, mus ob peb vas modulation, thiab cov leeg nqaij so, GABA qhov tseem ceeb yuav tsis tau overstated. Raws li peb txoj kev nkag siab ntawm GABAergic system txuas ntxiv mus, kev tshawb fawb tsis tu ncua thiab kho kev txhim kho lub hom phiaj GABA-txhim kho txoj hauv kev tuav cov lus cog tseg ntawm kev qhib txoj hauv kev tshiab rau kev tswj hwm ntawm ntau yam paj hlwb, kev puas siab puas ntsws, thiab neuromuscular mob. Qhov sib txawv thiab ntau yam xwm txheej ntawm GABA lub luag haujlwm qhia txog nws qhov tseem ceeb hauv kev tswj hwm tib neeg kev noj qab haus huv thiab kev noj qab haus huv.
Hongda Phytochemistry Co., Ltd. txaus siab rau nws daim ntawv teev cov ntawv pov thawj, suav nrog cGMP, BRC, ORGANIC (EU), ORGANIC (NOP), ISO22000, ISO9001, FDA, HALAL, KOSHER, thiab daim ntawv pov thawj lub teb chaws ntawm high-tech innovative enterprises. . Nrog rau ntau tshaj 30 xyoo ntawm kev paub, Shaanxi Hongda Hoobkas yog ib lub caij nyoog cov khoom xyaw manufacturers paub txog nws cov kev txawj ntse thiab kev cog lus rau zoo.
Peb lub Hoobkas nthuav dav, hla 20, 000 square metres, yog nruab nrog cov cuab yeej rho tawm siab heev thiab peb lub tsev SGS Certified Laboratory. Qhov chaw zoo tshaj plaws hauv lub xeev no qhia txog peb txoj kev mob siab rau kev tswj kom zoo thiab kev tsim khoom tshiab.
Kev tswj xyuas nruj nruj yog qhov tseem ceeb rau peb txoj haujlwm, thiab pebGamma Aminobutyric Acid Hmoovyog ib qho pov thawj rau qhov kev cog lus no. Yog tias koj tab tom nrhiav cov ncauj lus kom ntxaws txog cov khoom no lossis lwm yam kev nug, peb cov kws tshaj lij pab pawg tau npaj txhij rau kev sab laj ntawmduke@hongdaherb.com. Peb mob siab rau muab cov khoom zoo tshaj plaws thiab cov kev pabcuam raws li koj qhov kev xav tau tshwj xeeb.
Cov ntaub ntawv:
1, Brickley, SG, & Mody, I. (2012). Extrasynaptic GABA(A) receptors: lawv cov haujlwm hauv CNS thiab cuam tshuam rau tus kab mob. Neuron, 73(1), 23-34.
2, Brambilla, P., Perez, J., Barale, F., Schettini, G., & Soares, JC (2003). GABAergic dysfunction hauv kev xav tsis zoo. Molecular Psychiatry, 8(8), 721-737.
3, Knabl, J., Witschi, R., Hösl, K., Reinold, H., Zeilhofer, UB, Ahmad, S., Brockhaus, J., Sergejeva, M., Hess, A., Brune, K. , Fritschy, JM, Rudolph, U., Möhler, H., & Zeilhofer, HU (2008). Kev thim rov qab ntawm qhov mob pathological los ntawm cov leeg txha caj qaum GABAA receptor subtypes. Xwm, 451(7176), 330-334.
4, Möhler, H. (2012). GABA system hauv kev ntxhov siab thiab kev nyuaj siab thiab nws cov peev xwm kho tau. Neuropharmacology, 62(1), 42-53.
5, Winsky-Sommerer, R. (2009). Lub luag hauj lwm ntawm GABAA receptors nyob rau hauv lub physiology thiab pharmacology ntawm pw tsaug zog. European Journal of Neuroscience, 29(9), 1779-1794.
