Indole -3-carbinol (I3C)yog ib tug natural compound pom nyob rau hauv cruciferous zaub uas tau garnered xim rau nws muaj peev xwm noj qab haus huv cov kev pab cuam. Ib qho kev txaus siab yog I3C cov txiaj ntsig ntawm cov tshuaj estrogen hauv lub cev. Estrogen ua lub luag haujlwm tseem ceeb hauv kev loj hlob ntawm kev sib deev thiab kev ua haujlwm, tab sis kev tsis sib haum xeeb tuaj yeem ua rau muaj kab mob. Tsab ntawv xov xwm no tshuaj xyuas cov pov thawj tam sim no seb puas noj I3C tuaj yeem txo cov tshuaj estrogen.
Peb thawj zaug tshuaj xyuas seb Indole 3 Carbinol yog dab tsi thiab nws qhov chaw. Tom ntej no, peb tshawb nrhiav lub luag haujlwm ntawm estrogen thiab qhov cuam tshuam ntawm hormonal imbalances. Peb mam li txheeb xyuas cov kev tshawb fawb muaj nyob rau ntawm I3C lub peev xwm los txo cov tshuaj estrogen los ntawm ntau yam txheej txheem. Peb kuj tham txog Indole 3 Carbinol lwm cov txiaj ntsig kev noj qab haus huv thiab kev xav txog ntawm nws txoj kev siv nyab xeeb. Lub hom phiaj yog txhawm rau txheeb xyuas seb puas yog cov ntaub ntawv tshawb fawb tam sim no txhawb kev thov txog Indole 3 Carbinol cov tshuaj tiv thaiv estrogenic.
Indole -3-Carbinol yog dab tsi?
Indole-3-carbinol yog cov nroj tsuag ntuj tsim los ntawm kev tawg ntawm glucobrassicin, ib qho chaw pom muaj ntau hauv cov zaub cruciferous xws li zaub paj, zaub qhwv, zaub qhwv, thiab kale [1].
Hauv lub cev, I3C ua raws li phytochemical nrog ntau yam txiaj ntsig kev noj qab haus huv. Ntau qhov kev saib xyuas tau tsom tshwj xeeb rau nws cov tshuaj tiv thaiv estrogenic vim yog cov txheej txheem uas cuam tshuam rau cov tshuaj estrogen metabolism [2]. Raws li qhov tshwm sim, I3C tshuaj ntxiv tau loj hlob hauv qhov chaw.
Estrogen yog dab tsi?
Estrogens yog ib pawg ntawm poj niam txiv neej cov tshuaj hormones uas tsim nyog rau kev sib deev kev loj hlob thiab kev loj hlob. Peb qhov tseem ceeb tshwm sim estrogens hauv cov poj niam yog estradiol, estriol, thiab estrone. Cov tshuaj estrogen hloov thaum lub sij hawm lub sij hawm thiab pab tswj cov poj niam lub voj voog, ripeness, thiab pob txha noj qab haus huv [3].
Cov teeb meem tuaj yeem tshwm sim los ntawm cov tshuaj estrogen uas siab dhau lossis qis dhau. Kev pheej hmoo ntawm qee yam kab mob, xws li lub mis, zes qe menyuam, thiab kab mob endometrial, nce thaum cov tshuaj estrogen siab dhau vim tias nws txhawb nqa cell faib thiab loj hlob. Infertility, osteoporosis, thiab kab mob plawv yog tag nrho txuas rau cov tshuaj estrogen tsawg [4].
Kev noj zaub mov, lub cev hnyav, tshuaj, ib puag ncig muaj kuab paug, thiab kev noj qab haus huv tuaj yeem cuam tshuam rau cov tshuaj estrogen, ua kom ntsuas qib nyuaj [5]. Qhov no piav qhia txog kev txaus siab rau kev noj zaub mov zoo li I3C supplementation.
Indole puas tuaj yeem-3-Carbinol Lower Estrogen?
Raws li ntau yam kev tshawb fawb ntawm tib neeg, tsiaj txhu thiab cell kab lis kev cai,Indole 3 Carbinol hmoovtuaj yeem pab cov tshuaj estrogen metabolism thiab tshem tawm ntawm lub cev los ntawm cov txheej txheem sib txawv:
1. Ua kom nrawm nrawm ntawm cov tshuaj lom estrogens xws li 4-hyrdoxyestrone rau hauv cov ntaub ntawv tsis zoo xws li 2-hydroxyestrone. Qhov no hloov qhov piv rau kev tiv thaiv metabolites [6].
2. Txhawb detoxification enzymes nyob rau hauv daim siab uas pab txhawb estrogen clearance ntawm lub cev [7].
3. Kev khi rau cov tshuaj estrogen receptors, thaiv cov teebmeem ntawm cov tshuaj estrogen muaj zog zoo li estradiol [8].
Txawm li cas los xij, cov pov thawj tseem qhia tau hais tias cov teebmeem yuav nyob ntawm I3C ntau npaum li cas thiab cov qib tshuaj estrogen hauv paus. Piv txwv li, ib qho kev sim 6- hli hauv cov poj niam tom qab yug me nyuam noj 200mg lossis 400mg I3C txhua hnub pom tias tsis muaj qhov txo qis hauv cov zis estrogen [9]. Lwm txoj kev tshawb fawb qhia Indole 3 Carbinol txo qis cov tshuaj estrogen hauv cov poj niam premenopausal, tab sis tsis yog nyob rau hauv cov poj niam postmenopausal lossis txiv neej [10].
Cov teebmeem kuj tshwm sim muaj zog ntawm cov hauv paus ntsiab lus estrogen ntau dua. Ib qho kev sim rau cov poj niam uas muaj kev pheej hmoo siab mob mis rau 300mg I3C txhua hnub rau 4 lub lis piam tau pom tias txo cov tshuaj estrogen tseem ceeb piv rau cov placebo. Txawm li cas los xij, cov poj niam uas tsis tshua muaj tshuaj estrogen pom me ntsis nce [11].
Lwm cov txiaj ntsig kev noj qab haus huv ntawm Indole-3-Carbinol
Tshaj li kev hloov pauv tshuaj hormone, kev tshawb fawb qhiaIndole 3 Carbinol hmoovtuaj yeem muab lwm cov txiaj ntsig:
· Antioxidant Peev Xwm: Tsiaj thiab cov tube kev tshawb fawb qhia I3C thiab nws cov derivatives tuaj yeem txwv oxidative puas tsuaj los ntawm cov reactive dawb radicals heev [14]. Qhov no yuav txo tau cov kab mob. Tab sis tib neeg kev tshawb fawb tseem xav tau.
· Immune System Support: I3C qhia tau hais tias muaj peev xwm txhim khu kev tiv thaiv kab mob tiv thaiv kab mob thiab tiv thaiv cov lus teb tsis muaj zog. Tab sis feem ntau kev tshawb fawb yog preclinical.
Kev txiav txim siab thiab ceev faj
Thaum cog lus, nws yog ib qho tseem ceeb kom muaj kev cia siab tiag tiag txog I3C vim muaj kev txwv thiab qee zaum tsis sib haum rau tib neeg kev tshawb fawb. Cov txiaj ntsig yuav yog nyob ntawm cov koob tshuaj ntxiv, qhov ntev ntawm kev siv, thiab theem pib cov tshuaj hormones. Kev noj ntau kuj tseem tuaj yeem ua rau muaj kev phiv xws li xeev siab lossis thyroid tsis ua haujlwm. Cov tshuaj hormonal yuav tsum sab laj nrog kws kho mob ua ntej siv.
Lub Takeaway
Cov pov thawj tam sim no qhiaIndole 3 Carbinoltuaj yeem pab lub cev zoo metabolize thiab tshem tawm cov tshuaj estrogen. Cov ntaub ntawv ua ntej qhia tau hais tias cov teebmeem muaj zog tshaj plaws hauv cov neeg uas muaj cov tshuaj estrogen siab. Txawm li cas los xij, tus kheej hloov pauv muaj nyob hauv cov lus teb. Kev tshawb fawb ntxiv tseem yuav tsum tau ua kom paub meej thiab kho cov lus pom zoo txog kev noj tshuaj. Cov uas xav txog cov tshuaj I3C yuav tsum txheeb xyuas lawv cov keeb kwm kev noj qab haus huv ntawm tus kheej thiab cov hom phiaj nrog cov kws kho mob. I3C tseem yog ib qho tseem ceeb phytonutrient, tab sis tsis muaj cov mos txwv khawv koob rau kev noj qab haus huv.
Hongda Phytochemistry Co., Ltd. muaj qhov zoo ntawm kev tsim khoom ncaj qha, tso cai rau peb lees txais kev txiav txim raws li kev tsim khoom thiab ntim khoom. Peb nkag siab qhov tseem ceeb ntawm kev ua tau raws li cov kev cai tshwj xeeb, thiab peb pab neeg tau mob siab rau muab cov kev daws teeb meem.
Txhawm rau kom cov neeg siv khoom txaus siab, peb muab cov qauv dawb, tso cai rau koj kom paub txog qhov zoo ntawm peb cov khoom ua ntej. Tsis tas li ntawd, peb txoj kev cog lus rau kev tsim kho tshiab tau tshwm sim los ntawm peb lub rooj cob qhia tshiab capsule, uas ua rau peb tuaj yeem kho cov khoom siv tshuaj ntsiav raws li koj xav tau.
Peb koom tes nrog kev nthuav qhia thoob ntiaj teb, suav nrog cov xwm txheej tseem ceeb xws li European CPHI, European International Vitafoods, European Food Ingredients Exhibition FIE, Functional Food and Healthy Food Exhibition FFFI, American SSE, thiab ntau dua. Qhov kev tshwm sim thoob ntiaj teb no qhia txog peb txoj kev mob siab rau nyob rau hauv lub hauv paus ntawm kev lag luam thiab kev sib txuas nrog cov neeg siv khoom thoob ntiaj teb.
Ntawm peb cov khoom tshwj xeeb yog qhovIndole 3 Carbinol hmoov, uas boasts ntau qhov zoo tsim nyog tshawb nrhiav. Yog xav paub ntxiv txog cov khoom no lossis lwm yam kev nug, thov tsis txhob yig tiv tauj peb ntawmduke@hongdaherb.com. Peb tos ntsoov yuav muab koj cov khoom lag luam zoo thiab cov kev pabcuam uas ua tau raws li koj qhov kev xav tau tshwj xeeb.
Cov ntaub ntawv
[1] Higdon JV, Delage B, Williams DE, Dashwood RH. Cruciferous zaub thiab tib neeg kab mob txaus ntshai: cov pov thawj epidemiological thiab lub hauv paus txheej txheem. Pharmacol Res. 2007 Mar; 55(3):{4}}.
[2] Bradlow HL, Michnovicz JJ, Halper M, Miller DG, Wong GY, Osborne MP. Cov lus teb ntev ntev ntawm cov poj niam rau indole-3-carbinol lossis cov khoom noj muaj fiber ntau. Kab mob Epidemiol Biomarkers Prev. 1994 Aug; 3(7): 591-5.
[3] Nelson LR, Bulun SE. Estrogen ntau lawm thiab ua haujlwm. J Am Acad Dermatol. 2001 Sep; 45(3):S116-24.
[4] Kaňková K, Šulc M. Qhov cuam tshuam ntawm qhov tseeb thiab simulated weightlessness ntawm endocrine physiology. Endocr Regul. 2014 Mar;48(1):39-54.
[5] Diamanti-Kandarakis E, Bourguignon JP, Giudice LC, Hauser R, Prins GS, Soto AM, Zoeller RT, Gore AC. Endocrine-disrupting chemicals: Lub Koom Haum Endocrine scientific nqe lus. Endocr Rev. 2009 Lub Rau Hli; 30(4):293-342.
[6] Sepkovic DW, Bradlow HL, Michnovicz J, Murtezani S, Levine BS, Osborne MP. Catechol estrogen ntau lawm hauv nas microsomes tom qab kho nrog indole-3-carbinol, ascorbigen, los yog beta-naphthoflavone: kev sib piv ntawm ruaj khov isotope dilution gas chromatography-mass spectrometry thiab radiometric txoj kev. Cov tshuaj steroids. Peb Hlis 1994; 59(3): 318-23.
[7] Le HT, Schaldach CM, Firestone GL, Bjeldanes LF. Cog-derived 3,3'-diindolylmethane yog ib qho muaj zog androgen antagonist hauv tib neeg cov kab mob prostate. J Biol Chem. 2003 Lub Rau Hli 6; 278(23):21136-45.
[8] Chinni SR, Li Y, Upadhyay S, Koppolu PK, Sarkar FH. Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle capture and apoptosis in prostate disease cells. Oncogene. 2001 May 24; 20(23):2927-36.
[9] Reed GA, Peterson KS, Smith HJ, Grey JC, Sullivan DK, Mayo MS, Crowell JA, Hurwitz A. Ib theem kuv kawm txog indole-3-carbinol hauv cov poj niam: kam rau ua thiab cuam tshuam. Kab mob Epidemiol Biomarkers Prev. 2005 Aug; 14(8):{5}}.
[10] Neumannova V, Skodova V, Sedlackova E, Vrbikova J, Cimburek Z, Dvorakova G, Jakoubkova M. Cov nyhuv ntawm indole-3-carbinol thiab nws cov derivatives loj ntawm cov tshuaj hormones poj niam txiv neej thiab kev ua haujlwm antioestrogen hauv vitro. Physiol Res. 2019 Jan 24; 68(1):137-145.
[11] Dalessandri KM, Firestone GL, Fitch MD, Bradlow HL, Bjeldanes LF. Pilot txoj kev tshawb no: cov nyhuv ntawm 3,3'-diindolylmethane cov tshuaj ntxiv rau cov tshuaj urinary hormone metabolites hauv cov poj niam postmenopausal nrog keeb kwm ntawm cov kab mob hauv lub mis thaum ntxov. Nutr kab mob. 2004; 50(2): 161-7.
[12] Howells LM, Gallacher-Horley B, Houghton CE, Manson MM, Hudson EA. Indole-3-carbinol inhibits protein kinase B/Akt thiab induces apoptosis nyob rau hauv tib neeg lub mis qog cell kab MDA MB468 tab sis tsis nyob rau hauv nontumorigenic HBL100 kab. Mol Disease Ther. 2002 Dec; 1(13):{8}}.
[13] Tsvetkov P, Asher G, Reiss V, Shaul Y, Sachs L, Lotem J. Inhibition of NAD(P)H: quinone oxidoreductase 1 kev ua thiab induction ntawm p53 degradation los ntawm ntuj phenolic compound curcumin. Proc Natl Acad Sci US A. 2005 Plaub Hlis Ntuj 5; 102(14):5535-40.
[14] Reed GA, Sunega JM, Sullivan DK, Grey JC, Mayo MS, Crowell JA, Hurwitz A. Ib koob tshuaj pharmacokinetics thiab tolerability ntawm absorption-enhanced 3,3'-diindolylmethane hauv kev noj qab haus huv. Kab mob Epidemiol Biomarkers Prev. 2008 Oct; 17(10):2619-24.
